In severe cases, an overdose of Phenibut can lead to seizures and death. * In the United States, phenibut is legal to possess, but not approved as a drug authorized by the Food and Drug Administration (FDA). Although it is available online as a dietary supplement, the FDA has ruled that phenibut does not meet the definition of a dietary ingredient and cannot be listed as an ingredient in dietary supplements marketed in the United States (symbol www.fda.gov/food/dietary-supplement-products-ingredients/phenibut-dietary-supplementsexternal). The FDA analyzes the content of products containing phenibut, including the strength and purity of the ingredients; Few studies have been published describing the purity of products containing phenibut. Phenibut is closely related to a variety of other GABA analogues, including baclofen (β-(4-chlorophenyl)-GABA), 4-fluorophenibut(β-(4-fluorophenyl)-GABA), tolibbut (β-(4-methylphenyl)-GABA), pregabalin ((S)-β-isobutyl-GABA), gabapentin (1-(aminomethyl)cyclohexaacetic acid) and GABOB (β-hydroxy-GABA).   It has almost the same chemical structure as baclofen, is distinguished only by a hydrogen atom instead of a chlorine atom at the paraposition of the phenyl ring.  Phenibut is also close in structure to pregabalin, which has an isobutyl group at the β position instead of the phenyl ring of phenibut.  If you`re wondering if Phenibut is legal or not, you`re in the perfect place to get the answer. That is, it is not legal and therefore cannot be sold legally in the country. Side effects of phenibut include sedation, drowsiness, nausea, irritability, restlessness, dizziness and headache.
  An overdose of phenibut can lead to pronounced central nervous system depression, including loss of consciousness.   The drug is structurally related to the neurotransmitter γ-aminobutyric acid (GABA) and is therefore a GABA analogue.  Phenibut is believed to act as a GABAB receptor agonist, similar to baclofen and γ-hydroxybutyrate (GHB).  However, at low concentrations, phenibut slightly increases the concentration of dopamine in the brain and provides stimulant effects in addition to anxiolysis.  A chemical synthesis of phenibut has been published.  In addition, phenibut is not considered a legal and controlled substance in Asia due to the dependence and dependence it provides. The number of cases increased sharply during the study period, particularly since 2015, when regional poison centres were able to use “phenibut” as a relevant term to record exposures (figure). Phenibut exposures with known formulations most commonly affected solid (e.g. tablets) (65.1%) or powder (24.8%). Reported exposures were primarily through ingestion (93.2%), although 2.8% were inhaled and 4.0% were related to other routes of exposure, including dermal. Unintentional exposures were more common among those aged <18 years (21.9%). A significantly higher percentage of exposures in children aged <10 years (93.3%) were unintentional, compared to 6.3% in adults (S<0.001).
Concomitant substances (i.e. exposure to more than one drug or active substance) were reported in 29.6% of cases in <18 years of age and in 40.2% of all cases in adults (p=0.04). In case of overdose, phenibut can cause severe drowsiness, nausea, vomiting, eosinophilia, lowering blood pressure, renal dysfunction and more than 7 grams of fatty liver degeneration.   There are no specific antidotes for phenibut overdose.  Lethargy, somnolence, agitation, delirium, tonic-clonic seizures, decreased consciousness or loss of consciousness, and insensitivity have been reported in recreational users who overdose.  Treatment for phenibut overdose includes activated charcoal, gastric lavage, induction of vomiting, and symptom-based therapy.   There have been several fatal overdoses.  If you or a loved one is concerned about a potential problem with phenibut and need help stopping it, call Recovery Centers of America now (844-242-7956) where immediate, expert help is available 24 hours/day, 365 days/year.
Factors such as individual tolerance, contraindications and substances taken at the same time influence, among other things, safety. Between 2009 and 2019 U.S. Poison Control Centers reported concerns with phenibut poisoning for patients taking 700 mg or more at a time. The reason for the increase in phenibut-related exposures in 2009-2019 is unknown; The growing popularity and availability of the product by online retailers can contribute to this. The increase in phenibut exposure highlights the need for increased awareness of phenibut as an emerging substance for use and abuse in the United States. Adverse health effects reported in poison control centres, such as drowsiness or lethargy, agitation and confusion, are consistent with those described in previous reports (3). Exposures have been associated with long-term health effects, including death. Easy online access to phenibut (2) and the potential for addiction (5) are other concerns. Phenibut is uncontrolled and legal to possess in the United States. Education efforts to educate the public and clinicians about the emerging popularity and dangers of phenibut could help prevent adverse health effects and outcomes, including death. Phenibut risks include addiction, withdrawal, and death The generic name of phenibut is fenibut, phenibut or phenybut (Russian: фенибут).
 It is sometimes called aminophenylbutyric acid (Russian: аминофенилмасляная кислота).  The word phenibut is a contraction of the chemical name of the drug, β-phenyl-γ-aminobutyric acid.  In early publications, phenibut was called fenigam and phenigama (and its variant spellings; Russian: фенигам and фенигама).   No INNs were attributed to the drug.   As in the United States, it is also legal in Canada, but there are certain limitations to the purchase of phenibut. The 14 products identified by the CSPI generally fall into one of three regulatory categories: dietary supplements, food and pharmaceuticals. The FDA has stated in previous enforcement actions that phenibut is an adulterant in supplements and foods and is not approved for sale as a drug in the United States. The CSPI letter also identifies additional legal violations for products, for example when manufacturers imply that phenibut is a “food ingredient” if it does not meet the legal definition of that term. Companies that violate FDA rules by selling Phenibut could face criminal prosecution for violating federal law. But maybe you`re not sure if you can buy it legally or not. Any attempts at phenibut rejuvenation or withdrawal should be made under the supervision of a physician or qualified clinician.
Other care may also be warranted to treat the co-occurring mental health issues that contributed to phenibut abuse in the first place. Overall, that`s a yes, you can legally buy Phenibut in the US. It`s just that there are certain laws about it, you can`t call it a drug, and you can`t include it in the dietary ingredients either. In the United States and the European Union, it is not programmed or regulated, medically prescribed, or prohibited by law. The reason in the American context is that phenibut is essentially a chain of amino acids, leading to its classification by the FDA as a dietary supplement equivalent to vitamins and minerals. Therefore, online sellers can sell Phenibut legally and without regulation. However, this should not be confused with the fact that it is considered a safe supplement or drug. Phenibut has been identified as an abusive drug with many clinical effects in overdose and withdrawal syndrome in chronic use. Little information has been published on the clinical pharmacokinetics of phenibut.
 The drug would be well absorbed.  It spreads widely throughout the body and across the blood-brain barrier.  About 0.1% of an administered dose of phenibut enters the brain, which occurs to a much greater extent in both young and old people.  After a single dose of 250 mg in healthy volunteers, the elimination half-life was approximately 5.3 hours and the drug was largely excreted (63%) unchanged in the urine.  Phenibut also binds and blocks VDCC containing α2δ subunits, similar to gabapentin and pregabalin, and is therefore a gabapentinoid.   (R)-phenibut and (S)-phenibut show this effect with similar affinity (Ki = 23 and 39 μM, respectively).  Cases of phenibut overdose, also known as drug poisoning, have been reported.